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Liver Disease: Frequently Asked Questions

What are the symptoms of liver disease?

Mild or moderate liver disease may cause no symptoms at all. Severe liver disease causes water retention (swollen ankles, water in the abdomen or ascites), loss of energy and weakness, jaundice, blood vomiting or black stools, drowsiness, confusion or some behavioural changes, and repeated infections especially in the abdominal fluid (ascites). The common abnormalities in the blood tests are low blood counts (Hb, TLC, platelets), prolonged prothrombin time, low serum albumin and increased serum bilirubin. ...
As liver function is gradually lost from disease, some or all of these signs may appear: jaundice (yellow coloring of the skin and eyes) itching dark, tea colored urine clay-colored stools weight loss, muscle loss tendency to bruise and bleed easily ascites (fluid retention in the abdomen) or swollen legs/feet night blindness decreased energy and fatigue mental confusion which may progress to coma vomiting blood or passing blood in the stools
Some may experience flu like symptoms that might include fatigue, fever, muscle and joint aches, loss of appetite, and nausea. Other symptoms of liver disease include darkening of the urine, jaundice, easy bruising or bleeding.

How about liver disease?

In seven patients with chronic alcoholic liver disease, the AUC and Cmax of loratadine were double while the pharmacokinetic profile of descarboethoxyloratadine was not substantially different from that observed in other trials enrolling normal subjects. The elimination half-lives for loratadine and descarboethoxyloratadine was 24 hours and 37 hours, respectively, and increased with increasing severity of liver disease.

What is chronic liver disease?

This is liver disease that is seen when the liver has abnormal test results over a longer time frame, typically taking up to 10 years to establish true chronicity. Chronic liver disease may go on to form liver cirrhosis but this is not true of all chronic liver disease and close monitoring of the liver will establish whether this has happened.

What is liver disease?

Hepatitis C causes the liver to become inflamed, if this happened often enough the liver can become permanently damaged causing liver disease. The first sign of damage is scarring of the liver and is called fibrosis. If the fibrosis gets worse it develops into cirrhosis (this is just exactly the same as cirrhosis caused by alcohol abuse). Cirrhosis can cause problems such as; Ascites is a build up of fluid in the abdomen. Esophageal varices are varicose veins in the gullet, which can burst and lead to massive blood loss. ...

What is fatty liver disease?

This is a common liver disease associated with infiltration of fat in the liver. Although a number of conditions can cause fatty liver, the most common causes are alcohol use, obesity, and diabetes. A type of fatty liver called steatohepatitis can progress to cirrhosis in approximately 20% of patients.

What are the signs of liver disease?

COMMON SYMPTOMS: Some or all of the following symptoms may be present: 1. Intermittent, recurrent abdominal or gastrointestinal upsets. Loss of appetite, vomiting, diarrhea, constipation. 2. Progressive depression or lethargy. 3. Swollen belly with a fluid-filled look. This is known as "ascites" and is actually fluid accumulation in the belly due to circulation alterations in the abdomen. 4. Pale gray feces. Bile pigments are what give feces its characteristic brown color. 5. Orange urine. ...

What are the types of cholestatic liver disease?

• Biliary atresia • Idiopathic neonatal hepatitis • Alagille Syndrome • Alpha-1 Antitrypsin Deficiency (Alpha-1) • Bile Acid Synthesis Defect • Progressive Familial Intrahepatic Cholestasis (PFIC) • Mitochondrial Hepatopathy >back to top of page Caring for a Child with Cholestatic Liver Disease

What are signs of infant liver disease?

In a baby there can be one or more signs that the liver is not working properly. The skin and eyes may be jaundiced (appear yellow). Jaundice is caused by a buildup of bilirubin in the blood. The abdomen may look swollen or stick out. The urine may be dark yellow or brown. The stools are often grey or white instead of green or yellow. There may also be bleeding or easy bruising. The blood might contain higher than normal levels of liver enzymes. The liver may feel large or look large on an x-ray. ...

What are the usual symptoms of liver disease?

Usual symptoms of liver disease are jaundice (yellow discoloration of the eyes), dark coloured urine, itching, vomiting of blood, ascites (accumulation of fluid in the abdomen), easy bruisability or tendency to bleed, and mental confusion. Many people with liver disease have non-specific symptoms only (loss of desire to eat, nausea, weight loss, lethargy, and general feeling of not being well).
Usual symptoms of liver disease are jaundice (yellow discoloration of the eyes), dark coloured urine, itching, vomiting of blood, ascites (accumulation of fluid in the abdomen), easy bruisability or tendency to bleed, and mental confusion. Many people with liver disease have non-specific symptoms only (loss of desire to eat, nausea, weight loss, lethargy, and general feeling of not being well). Top 17

What is acute liver disease?

A person develops acute liver disease over a short time period, between a week and six months with associated symptoms including extreme nausea and vomiting and abdominal pain from swelling of the liver. If the symptoms of yellowing of the eyes and confusion occur then this is termed Fulminant Hepatic Failure (FHF) and indicates that the progress of the disease may be more extensive and you should see a Hepatologist immediately. ...

Is there a specialist who treats liver disease?

All gastroenterologists are trained in liver disease to some extent, but there are physicians who are trained specifically in liver disease (hepatologists).

What is the treatment for liver disease?

Treatment options for liver disease will depend upon your health condition. Sometimes liver disease may best be treated by medical interventions. Severe liver disease may require medical and surgical intervention. For example, you may benefit from surgical intervention such as a shunt procedure. ...

What are some of the symptoms of liver disease?

People who have liver disease may have some of the following symptoms. If you have any of these symptoms and have not already discussed them with your doctor, it is important to do so immediately . Yellow discoloration of the skin and eyes called jaundice Itching from the build up of bile salts in the skin Loss of muscle and strength in your arms and legs Tea-colored urine Gray or clay-colored stools Mental confusion, sleep disturbance or coma Abnormal accumulation of fluid in the abdomen (ascites) Tendency ...
The most important thing to recognize about liver disease is that up to 50 percent of individuals with underlying liver disease have no symptoms. The most common symptoms are very non-specific and they include fatigue or excessive tiredness, lack of drive, occasionally itching. ...

What is end stage liver disease?

End stage liver disease is the final stage of liver failure. It includes symptoms like yellowing of the skin (jaundice), itching, dark colored urine, gray or clay colored stools, ascites (fluid collection in the abdomen), encephalopathy (mental confusion), coma, easy bruising, intestinal bleeding and fatigue. In general, people who qualify for liver transplantation have end stage liver disease.

How is end-stage liver disease managed?

Treatment of end-stage liver disease depends on its cause. Since Emory is a major academic transplant center, we have access to the most advanced research protocols with the latest drugs and technology to treat patients with liver disease. (return to top) BECOMING A CANDIDATE

What are the signs and symptoms of liver disease?

Typical signs include fatigue and weakness, nausea and vomiting, loss of appetite and weight loss, itchy skin, jaundice and fluid in the abdomen.

Are there alternative treatments for liver disease?

There are effective medicines for some liver diseases, while for others only palliative treatment for complications is available. Treatment of complications may be all that is required if the liver is not failing. Frequently medical treatment delays, but does not eliminate, the need for transplantation.
There are effective medicines for some liver diseases, while for others only treatment for complications is available. Treatment of complications may be all that is required if the liver is not failing. Frequently medical treatment delays, but does not eliminate, the need for transplantation.

Who are more susceptible to alcoholic liver disease?

Women may be more susceptible than men. Alcoholic liver disease may not affect all heavy drinkers. In some people, the rate of alcohol metabolism can be high enough to allow for the consumption of large quantities of alcohol without raising the alcohol level in blood .

What is the life expectancy of a child with a cholestatic liver disease?

The answer to this question depends a great deal on the specific diagnosis.
There are many factors that determine life expectancy. To optimize life expectancy requires attention to providing adequate care and treatment.

Liver disease - are there warning signals?

Yes. You feel exhausted, drained. After getting up in the morning, you feel like going straight back to bed. Your eyes are glassy, and tiny red or blue blood vessels may appear under your eyes. Your stomach feels uncomfortably bloated. You feel hungry, but you don't feel like eating.

How Do We Get Fatty Liver Disease?

It's unclear exactly what causes nonalcoholic fatty liver disease. But many researchers believe that metabolic syndrome - a cluster of disorders that increase the risk of diabetes, heart disease and stroke - likely plays an important role in its development. Researchers suspect that there may be a genetic component to the disorder.

What other factors can affect Fatty Liver disease?

These factors include total parenteral nutrition (TPN), rapid weight loss, intravenous glucose therapy and surgical removal of large portions of the small intestine or stomach to treat severe obesity.

Can children with a cholestatic liver disease participate in regular physical activity?

The jaundice itself does not mean that your child should be excluded from regular physical activity. However sometimes children with cholestatic liver diseases develop big spleens and should not participate in contact sports. Also these children may have brittle bones which can easily be broken so for that reason also contact sports might not be a good idea.

Is chemical dependency a liver disease which may trigger a neurological disease?

No. It is a chronic neurological disease with a high risk of relapse which may trigger a number of secondary medical diseases, such as AIDS, Cirrohrosis, and heart disease. Q14.
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