Aldactone, Spironolactone (generic): Frequently Asked Questions
What is spironolactone?
It’s a medication that has been used for more than 30 years to treat hypertension and fluid retention. Regrowth offers a 2% spironolactone in 60 mL bottles with a dabber applicator and a 2oz jar of 5% Spironolactone Lotion. The pharmaceutical effects of topical spironolactone are local to the skin where it is applied and there are no systemic effects from its use on the scalp.
Source: www.minoxidil.com
Spironolactone is a potassium-sparing diuretic. It has the same effect as Lasix, but doesn't affect potassium metabolism. Why is my cat taking Aspirin? I thought it was toxic to cats. Your cat is taking Aspirin in the hope that it will help prevent blood clots. Studies are inconclusive as to whether Aspirin does reduce the risk of throwing a clot. Most vets will prescribe it for cats that are at high risk of developing clots because something is better than nothing. ...
Source: ca.geocities.com
Does the 5% Spironolactone Lotion has an unpleasant odor associated with it?
We seldom have complaints regarding the odor from 5% spironolactone lotion. But patients with a heightened sense of smell have complained. When spironolactone is incorporated into a lotion form, the odor is minimized because there is no volatile substance to disperse the scent. AZELAIC ACID
Source: www.minoxidil.com
What does spironolactone have to do with male pattern baldness?
There are three distinct benefits of topical spironolactone in its use as a treatment for MPB. (1). Spironolactone significantly reduces the amount of DHT in the scalp by inhibiting the conversion of precursor steroids to DHT. (2). Spironolactone reduces the DHT in the scalp by converting localized testosterone into estrogen, which is thought to be protective of the hair follicles. ...
Source: www.minoxidil.com
What are topical spironolactone’s side effects?
Spironolactone is rapidly and completely metabolized in the skin and does not affect any other organ system. In about 1% of patients, a rash can develop. If this happens, the patient should discontinue use of topical spironolactone. .
Source: www.minoxidil.com
Are there any drawbacks to the use of topical spironolactone?
Although topical spironolactone is pharmacologically one of the most effective topical treatments for MPB, there are inherent drawbacks, e.g. spironolactone has a disagreeable odor, which is enhanced by evaporation of the alcohol when it’s in solution form
Source: www.minoxidil.com
Does the 5% Spironolactone Lotion have an unpleasant odor associated with it?
We seldom have complaints regarding odor associated with the 5% spironolactone lotion, although a few patients, who have a heightened sense of smell, have complained. When spironolactone is incorporated into a lotion form, the odor is minimized because there is no volatile substance to disperse the scent.
Source: www.minoxidil.com
What does spironolactone have to do with treating male pattern baldness?
There are three distinct benefits of topical spironolactone in its use as a treatment for MPB. (1). Spironolactone significantly reduces the amount of DHT in the scalp by inhibiting the conversion of precursor steroids to DHT. (2). Spironolactone reduces DHT in the scalp by converting localized testosterone into estrogen, which is thought to be protective of the hair follicles. ...
Source: www.minoxidil.com
Should one use the 5% Spironolactone Lotion in conjunction with Xandrox15?
For most patients, it shouldn’t be necessary. The azelaic acid in Xandrox15 inhibits the synthesis of DHT in almost all cases. However, if one opts to use a 5% minoxidil solution without azelaic acid for the second application of the day, then the additional use of the 5% Spironolactone Lotion is advisable. Most patients use the 5% Spironolactone Lotion at night. Apply the Xandrox15 solution first. Allow 10-15 minutes for it to partially dry. ...
Source: xandrox15.com
Should one use the 5% Spironolactone Lotion in conjunction with Xandrox15-PLUS?
For most patients, it shouldn’t be necessary. The azelaic acid and the finasteride in Xandrox15-PLUS should provide adequate reduction of DHT in the scalp.
Source: www.minoxidil.com
Will my hair have an unpleasant odor if I use spironolactone?
It may. We've worked with a well-known pharmacologist and a reliable biochemical laboratory to produce a 2% a Spironolactone solution that minimizes the offensive odor and remains under control at room temperatures. Nevertheless, do not apply spironolactone solutions before strenuous exercise, as excess body heat can degrade the spironolactone resulting in an unpleasant odor. To avoid this odor, apply the spironolactone solutions only before going to bed at night, and then shampoo your scalp in the morning. ...
Source: www.minoxidil.com
It may. We've worked with a well-known pharmacologist and a reliable biochemical laboratory to produce a 2% a Spironolactone solution that minimizes the offensive odor and remains under control at room temperatures. Nevertheless, do not apply spironolactone solutions before strenuous exercise, as excess body heat can degrade the spironolactone resulting in an unpleasant odor. To avoid this odor, apply the spironolactone solution only before going to bed at night, and then shampoo your scalp in the morning. ...
Source: www.minoxidil.com
Why haven’t other doctors used topical spironolactone to treat male pattern baldness?
Although topical spironolactone is pharmacologically one of the most effective topical treatments for MPB, there are inherent drawbacks, e.g. spironolactone has a disagreeable odor, which is enhanced by evaporation of the alcohol in the solution.
Source: www.minoxidil.com
Since Regrowth, LLC made topical spironolactone available to treat MPB in 2001, numerous other medical practices have also offered it.
Source: www.minoxidil.com
Why didn’t you put spironolactone directly into your minoxidil solutions, so it would have been more convenient to use?
When minoxidil and spironolactone are combined in the same solution, they will chemically react within a few days and degrade each other, causing a particularly offensive odor. Since this chemical reaction requires many hours to occur, the reaction does not occur if minoxidil and spironolactone are applied to the scalp one after the other from separate containers.
Source: www.minoxidil.com
When minoxidil and spironolactone are combined in the same solution, they will chemically react and degrade each other, causing a particularly offensive odor. Since this chemical reaction requires many hours to occur, the reaction does not occur if minoxidil and spironolactone are applied to the scalp one after the other, from separate containers.
Source: www.minoxidil.com
What's the advantage of using 5% Xandrox ® over Regrowth's 5% minoxidil along with 2% or 5% spironolactone?
Better patient compliance. It's more convenient, since each topical dose only requires a single 1 mL application from one bottle. 5% Xandrox ® is odorless as compared to the offensive odor that can be associated with spironolactone. However, in terms of efficacy in treating MPB, topical minoxidil combined with either azelaic acid or spironolactone often yields the same results.
Source: www.minoxidil.com
Better patient compliance. It's more convenient, since each topical dose only requires a single 1 mL application from one bottle. 5% Xandrox® is odorless as compared to the offensive odor that can be associated with spironolactone.
Source: www.minoxidil.com
How much more effective are 5% Xandrox ® solutions as compared to using plain minoxidil solutions or the combination of minoxidil and spironolactone solutions?
Unfortunately, after almost two decades of use and evaluation, it is obvious that minoxidil solutions used alone have not been significantly effective for reversing MPB for the majority of patients. However, when minoxidil is combined with an inhibitor of 5-alpha reductase, the majority of patients will have positive visible results in growing scalp hair. The major problem with the use of topical 2% or 5% spironolactone is lack of compliance in its use rather than effectiveness. ...
Source: www.minoxidil.com
If I’m using Xandrox ® or topical spironolactone, should I continue to take finasteride to lower the DHT level in the whole body?
Finasteride works systemically and will lower the serum level of DHT throughout the body. Xandrox ® works only where it is applied. If you are not having side effects from finasteride, it may be advantageous to continue taking finasteride to protect the hair on the scalp not yet affected by MPB, but is 'at risk. ' For patients with large areas of thinning hair, it may be advantageous to take finasteride in addition to using Xandrox ® 5% solution and/or topical spironolactone.
Source: www.minoxidil.com
Oral finasteride works systemically and will lower the serum level of DHT throughout the body. Xandrox® works only where it is applied. If you are not having side effects from finasteride, it may be advantageous to continue taking finasteride to protect the hair on the scalp not yet affected by MPB, but is 'at risk. ' For patients with large areas of thinning hair, it may be advantageous to take finasteride in addition to using Xandrox® 5% solution and/or topical spironolactone.
Source: www.minoxidil.com
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