DDAVP, Stimate, Desmopressin (generic): Frequently Asked Questions
Is it reduced with desmopressin (dDAVP)?
Familial CDI, which seems to be the type that runs in your family, has no appreciable effect on GFR unless lack of treatment leads to permanent bladder distention, incomplete drainage, infections, and chronic pyelonephritis. This complication is uncommon, however, even in patients who are not treated for their CDI. Desmopressin has no direct effect on GFR that I am aware of. It may increase it indirectly by increasing total body water but this effect is probably quite small. ...
Source: www.diabetesinsipidus.org
Is there a difference in the generic desmopressin and the brand name dDAVP?
I am not sure why you experience heavy pressures in your chest before and after your doses of dDAVP. If may be due to rapid shifts in body water, particularly if you are taking the drug in such a way as to allow the effects of one dose to wear off before taking the next dose. If so, you should talk with your doctor about the possibility of taking the dDAVP on a more regular schedule that prevents intermittent escape. ...
Source: www.diabetesinsipidus.org
Is there a difference between the generic drug desmopressin and the brand name dDAVP?
As far as we know, there is no chemical difference in the generic and brand name, but there could be a difference in the vehicle (solution in which it is dissolved) that affects stability or the absorption of the drug. If you are having problems with variable effectiveness, you might try the brand name or switch to a different route of administration. ****** Top of Page ****** Question # 0066 FAQ Keywords: treatment, CDI medications, DDAVP, CDI side effects, pregnancy I take chlorpropamide and chlorathiazide for CDI. ...
Source: www.diabetesinsipidus.org
What is DDAVP?
DDAVP is a synthetic chemical that is almost identical to a naturally occurring chemical, anti-diuretic hormone (AHD) that is made in the hypothalamus part of the brain. ADH controls the amount of urine made by the kidneys. If there is not enough ADH, the kidneys make too much urine, and vice versa.
Source: www.childrensclinic.ca
How does DDAVP work?
Early forms of DDAVP were first used to treat bedwetting in the 1960’s. The physicians tried the medication in the hope that if the kidneys produced less urine that the wetting might improve. The wetting did improve in some children and in the 1980’s a group of Danish doctors published research that suggested that the levels of ADH were low at night in some individuals who wet the bed. ...
Source: www.childrensclinic.ca
What is the dosage of dDAVP?
The dose of dDAVP required to control CDI does vary with the size of the patient. However, it cannot be specified exactly in terms of body weight because other factors, such as differences in absorption or metabolism, also exert a major influence. Therefore, the optimum dose varies quite widely from patient to patient and must be determined by trial and error. The dose also depends on the route of administration. ...
Source: www.diabetesinsipidus.org
How does the medication DDAVP work?
One of the body’s natural nighttime functions is to make the hormone ADH, which reduces the amount of urine our kidneys make. Some people who wet make too little of this hormone, and this medication gives it a “boost.” The medication can help restore the nightly rhythm, but may or may not correct the wetting permanently.
Source: www.tryfordry.com
What are the side effects of DDAVP?
DDAVP has the best side effect profile of all the medications currently available to treat bedwetting. The tablets have a better side effect profile than the nasal spray. A serious and preventable side effect of DDAVP is water intoxication with resultant seizure or other central nervous system symptoms. DDAVP limits the amount of urine that the kidney will produce. If a child drinks a lot of fluids while taking DDAVP, the water will build up in the body and change the chemical (sodium) composition of the blood. ...
Source: www.childrensclinic.ca
What are the known side effects of DDAVP?
There are no side effects of dDAVP except water intoxication. If you are experiencing unusual psychological changes on treatment, you should have your plasma sodium checked to see if it is low, a sign of water intoxication. ****** Top of Page ****** Question # 0056 FAQ Keywords: DDAVP, side effects, psychological changes, children with CDI My son has both CDI and night terrors. ...
Source: www.diabetesinsipidus.org
Are dDAVP tablets as effective as the nasal spray?
At effective doses, dDAVP tablets are not less expensive than dDAVP nasal spray. They are more convenient and often as effective as the spray. However, in some patients, their effects are more erratic owing to variations in absorption from the gut. This variability sometimes can be prevented or reduced by taking the tablets on an empty stomach, but other times it is necessary to go back to the nasal spray. ...
Source: www.diabetesinsipidus.org
Why does my dDAVP not always work properly?
If your dDAVP treatment works poorly sometimes, the reason is probably poor absorption of the drug. If you are taking the dDAVP by mouth, you may be able to improve consistency by taking the tablet on an empty stomach or by increasing the size or frequency of the dose. If you are taking the nasal spray, try blowing your nose before each dose. If that does not help, consult your doctor about increasing the size or frequency of the dosing. ...
Source: www.diabetesinsipidus.org
What are the effects of stress on dDAVP absorption and the pituitary gland itself?
As far as we know, stress does not affect dDAVP absorption, although it might increase the metabolism or disposition of the drug. ****** Top of Page ****** Question # 0330 EWv3n2, 0080 FAQ Keywords: dosage, DDAVP, nasal spray My timing between doses of dDAVP varies. For the nasal spray it can vary from 6 hours to 18 hours.
Source: www.diabetesinsipidus.org
Will the dDAVP affect schoolwork in the future?
DDAVP has no known long-term effects and should not affect schoolwork in the future. ****** Top of Page ****** Question # 0047 FAQ Keywords: treatment, CDI medications, DDAVP
Source: www.diabetesinsipidus.org
Is the dDAVP tablet better if given on an empty stomach ?
Food may affect the absorption of dDAVP in the gastrointestinal tract, so it is probably better to take the tablet on an empty stomach. ****** Top of Page ****** Question # 0278 EWv2n4, 0069 FAQ Keywords: DDAVP, dosage
Source: www.diabetesinsipidus.org
How long does dDAVP last in the body?
The body does not store dDAVP, but it can accumulate if it is given faster than the body disposes of it. The half-life varies markedly from person to person but averages around 1 to 2 hours. The antidiuretic effect of the usual intranasal dose also lasts for variable periods of time not only because of variations in half-life but also in absorption of the drug. On average, however, it is about 8 to 12 hours, or 4 to 6 half lives, because the initial blood levels achieved are greater than necessary to produce antidiuresis. ...
Source: www.diabetesinsipidus.org
What are the long-term side effects of taking dDAVP?
Research into a cure for CDI is being conducted, but there are no promising leads at present and it is unlikely that a cure will be available anytime soon. Fortunately, a good treatment (dDAVP) is available to control the disorder. A better treatment for NDI is also being actively investigated and, although the leads there are a little more promising, it will likely be some time before it is routinely available. ...
Source: www.diabetesinsipidus.org
Does dDAVP work equally well with the nasal spray and the tablet?
DDAVP tablet and dDAVP nasal spray work equally well overall, although certain patients do better on one than the other, probably because of individual differences in the efficiency of absorption from the nose and gastrointestinal tract. ****** Top of Page ****** Question # 0750 EWv7n3 Keywords: cure, prognosis, CDI side effects, DDAVP, treatment
Source: www.diabetesinsipidus.org
Is it ever necessary to increase dDAVP doses?
The dose of dDAVP required to control CDI should not change over time, unless the patient is a growing child, in which case it may increase gradually in proportion to size. If the dose of dDAVP required to control CDI does increase significantly, it is usually because the efficiency of absorption has decreased (for example, when a patient using the nasal spray develops hay fever or a cold). Occasionally, the dose requirements increase because the patient develops antibodies to dDAVP, but this is very rare. ...
Source: www.diabetesinsipidus.org
Is there any known bad effect of dDAVP after very long use?
Using dDAVP for a long time has not produced any bad effects that we know about. ****** Top of Page ****** Question # 0429b EWv4n2, 0085 FAQ Keywords: hyponatremia, DDAVP, CDI side effects, dipsogenic DI, diagnosis, children with CDI
Source: www.diabetesinsipidus.org
Does dDAVP work equally well between with the nasal spray or the tablet?
DDAVP tablet and dDAVP nasal spray work equally well overall, although certain patients do better on one than the other, probably because of individual differences in the efficiency of absorptions from the nose and gastrointestinal tract. ****** Top of Page ****** Question # 0276 EWv2n4, 0072 FAQ, 0729 EWv7n2 Keywords: tablets, DDAVP
Source: www.diabetesinsipidus.org
Is dDAVP better given in the morning or evening?
In most patients with uncomplicated CDI, dDAVP should be given as often and in as large a dose as necessary to completely normalize the rate of urine output. This is usually achieved most conveniently by giving at least two doses, one in the morning and one at bedtime. If necessary, a third dose can be given in the late afternoon. ...
Source: www.diabetesinsipidus.org
Why do children wet when they stop DDAVP?
The action of DDAVP is to decrease the quantity of urine produced that night. When the medication is stopped, the body resumes making a larger quantity of more dilute urine. If the bladder has grown to accommodate more urine or your child has learned to wake to messages from the bladder, he may have continued success in staying dry. In most cases, however, the wetting resumes when the medication is stopped. Q: I wake my child and take him to the bathroom before I go to bed.
Source: www.bedwettinghandbook.com
Is there any other medication other than dDAVP to control symptoms, without as many side effects as dDAVP?
DDAVP has few side effects in patients with uncomplicated CDI. It may produce water intoxication if the thirst mechanism is abnormal or if the patient does not remember to restrict his or her drinking to times when he or she is truly thirsty. ****** Top of Page ****** Question # 0073 FAQ Keywords: DDAVP, dosage
Source: www.diabetesinsipidus.org
Why does my son have lower back (kidney) discomfort when dDAVP wears off?
The symptoms you describe may be caused by a sudden increase in urine output that distends the ureters. However, you should discuss it with his physician to be sure that further investigations for another cause are not warranted. ****** Top of Page ****** Question # 0653 EWv6n3 Keywords: CDI medications, CDI side effects, alternative medications, DDAVP, desmopressin, CDI complications I have CDI. ...
Source: www.diabetesinsipidus.org
Are there other medications than dDAVP that can be used for CDI?
Many patients with CDI take dDAVP instead of chlorpropamide because their doctors do not know how effective the latter can be. Chlorpropamide can lower blood sugar. Usually this does not have any consequences except for a slight increase in appetite, sometimes weight gain, and occasionally irritability. However, the low blood sugar can be more severe if the patient goes on a strict diet or engages in heavy physical exercise. The drug should not be taken during pregnancy since we do not know if it affects the fetus. ...
Source: www.diabetesinsipidus.org
Should CDI patients wait for symptoms to appear before taking dDAVP?
In the usual patient with uncomplicated CDI, there is no need or benefit to waiting for symptoms to appear before taking the next dose of dDAVP. It is preferable to take the drug in doses or with a frequency that prevents breakthrough because this regimen is not only more convenient, it minimizes fluctuations in hydration, which, in the long run, may have deleterious effects. ...
Source: www.diabetesinsipidus.org
How does dDAVP work in my body? Does it go to my pituitary first or my kidneys?
DDAVP is absorbed into the bloodstream and taken directly to the kidneys where it acts to concentrate the urine and, thereby, reduce urine output. ****** Top of Page ****** Question # 0054 FAQ, 0277 EWv2n4 Keywords: DDAVP, prognosis
Source: www.diabetesinsipidus.org
Can I take desmopressin when I breakthrough (feel the symptoms of DI) or should I stick to regular times?
Do you mean that your DI sometimes stops even when you do not take dDAVP? That is very unusual for CDI and, if present, it would suggest that you are a smoker or have a second problem such as postural hypotension or adrenal insufficiency, any one of which can mask DI. ...
Source: www.diabetesinsipidus.org
How does Novo-Desmopressin work? What will it do for me?
Desmopressin belongs to a class of medications called antidiuretics. It can be used to prevent nocturnal enuresis (bedwetting) in children 5 years of age or older. In this case, it is often used in combination with nonmedication treatments, such as motivational counselling and bladder exercises. It works by helping reduce the amount of urine produced by the kidneys at night. ...
Source: health.lifestyle.yahoo.ca
Do you know if fertility studies have been conducted on CDI women or if dDAVP is used before and during pregnancy?
CDI itself does not cause infertility but some of the diseases that cause CDI occasionally do so. If you truly have CDI (and not dipsogenic DI) it is perfectly safe to take dDAVP before and during pregnancy. It does not affect fertility or the unborn fetus, provided you remember to drink only when you are thirsty. Your serum sodium level will normally be lower (by 5 mEq/l) during pregnancy. ****** Top of Page ****** Question # 0576 EWv5n4 Keywords: menstruation, weight gain Before having DI my menstrual period was normal. ...
Source: www.diabetesinsipidus.org
