Zanaflex, Tizanidine (generic): Frequently Asked Questions
What are Zanaflex Capsules™ (tizanidine hydrochloride)?
Zanaflex Capsules are a multiparticulate capsule formulation of tizanidine hydrochloride. Zanaflex Capsules are a short-acting drug indicated for the management of spasticity. Because of the short duration of effect, treatment with Zanaflex Capsules should be reserved for those daily activities and times when relief of spasticity is most important. Pharmacokinetic differences exist between Zanaflex Capsules and Zanaflex tablets and generic tizanidine. ...
Zanaflex Capsules are a short-acting drug for the management of spasticity. Because of the short duration of effect, treatment with Zanaflex Capsules should be reserved for those daily activities and times when relief of spasticity is most important. Important Safety Information You should not take Zanaflex Capsules™ (tizanidine hydrochloride) if you are currently taking fluvoxamine (Luvox®) or ciprofloxacin (Cipro®). Talk to your doctor if you have liver disease or liver damage. ...
What is Zanaflex?
Zanaflex is the brand name of Tizanidine Hydrochloride and is manufactured by Elan Pharmaceuticals based in San Diego, California, USA. Zanaflex is a FDA-approved prescription muscle relaxant . You can buy Zanaflex by going to our Zanaflex price comparison page where you can select your preferred online US pharmacy with the lowest Zanaflex prices, no prior prescription required . ...
How safe is Zanaflex?
Zanaflex has been used as a muscle relaxant since 1996. Its safety and efficacy profile have been maintained by real-world experience as well as clinical trials. Zanaflex has been approved by the FDA to successfully and safely treat increased muscle tone associated with spasticity (muscle twitching). However, Zanaflex may not be for everyone. Make sure to read about Who should not take Zanaflex? .
What is generic Zanaflex and is it available?
Zanaflex’s generic name is Tizanidine . Generic formulations of Zanaflex 2mg and 4mg are available from various manufacturers for sale in the US.
How does Zanaflex work?
Zanaflex does not act directly on muscle or at the nerve-to-muscle communication point. It is thought that it reduces muscle spasms by blocking spinal nerve communication.
Are Zanaflex Capsules equivalent to Zanaflex tablets?
No, Zanaflex Capsules are a different formulation of tizanidine hydrochloride. Zanaflex Capsules are not equivalent to tizanidine tablets. Zanaflex Capsules and Zanaflex tablets exhibit different pharmacokinetics under fed conditions. When administered with food, the amount absorbed from the capsule is about 80 percent of the amount absorbed from the tablet. These differences may influence the likelihood of adverse events and change the onset of activity. ...
Before taking this drug, tell your doctor if you have: any allergies, low blood pressure, liver or heart disease, kidney disease, eye disease. Limit the use of alcohol as alcohol may intensify the dizziness and drowsiness effects of this drug. Use caution when driving or operating machinery or when alertness is required. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug is excreted into human milk. ...
This medication is used to treat muscle spasms.
Take as directed. Your dosage will probably need to be adjusted by your doctor initially to achieve satisfactory results. Follow directions exactly
Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture.
How well does Zanaflex work?
One study of patients with multiple sclerosis showed that patients who received Zanaflex had a greater reduction of muscle tone versus sugar pill at 1, 2 and 3 hours after treatment, this advantage no longer seen by 6 hours. Another study of patients with spasticity (muscle twitching) due to spinal cord injury showed that patients who received Zanaflex had a greater reduction of muscle tone without losing muscle strength versus sugar pill.
What are the possible side effects of Zanaflex?
The most common side effects are dry mouth, drowsiness, tiredness and dizziness. These side effects increase as dose increases. Stop taking Zanaflex and contact your doctor immediately if you have signs of an allergic reaction such as a rash, or hives. Zanaflex can occasionally cause liver damage. Your doctor may periodically do simple blood test to monitor your liver function. Side effects other than those listed here may also occur. ...
What are the possible drug interactions of Zanaflex?
Inform your doctor, during either a physical or online consultation, about all the medicines you use, prescription and non-prescription. Certain medicines should never be used together. Some medicines may be used together even if an interaction might occur. In these cases, your doctor may change the dose, monitor the effects or take other precautions. ...
How do I take Zanaflex?
Zanaflex comes in 2mg and 4mg tablets. Always take Zanaflex as directed by your doctor. Do not take more medication than prescribed. Usual Adult Dose Oral dosage form (Tablets) – Therapy is usually started at 4mg and gradually increased by 2-4mg to 8mg three times daily with 6 to 8 hours between doses. The maximum daily dose is 36mg. There is limited clinical data on long-term use of Zanaflex. Your doctor may have a plan that varies from above, always follow your doctor’s recommendations.
What are symptoms of a possible Zanaflex overdose?
Symptoms of overdose may include decreased breathing rate coma. If overdose is suspected, call your doctor, emergency medical services (EMS) 911, or the poison control center immediately. National Poison Control Center telephone number: 800-222-1222
How should I store Zanaflex?
Keep Zanaflex and all medications out of children's reach. Store Zanaflex at room temperature in a tight container. Store away from moisture, heat and direct light. Do not keep medicine past the expiration date, dispose of properly.
How much does Zanaflex cost?
Some companies charge less per pill but charge you separately for their consultation and pharmacy dispensing fees. Others include these fees into their final pricing. RxPriceCheck's featured pharmacies give you a free online medical consultation with your order. Be sure to compare Zanaflex prices before buying. Usually, the more pills you buy, the cheaper the price per pill. ...
What does Zanaflex look like?
Zanaflex manufactured by Elan Pharmaceuticals based in San Diego, California, USA, is available as 2mg and 4mg tablets. Zanaflex 2mg tablets are round, white, with the imprint A 592 on one side, and scored on the other side. Zanaflex 4mg tablets are round, white, with the imprint A 594 on one side, and double-scored on the other side.
Will Tizanidine help control or reduce dystonia?
Medications we commonly use to control the symptoms of dystonia are Klonipin and Artane. Tizanidine may be reasonable to try as well. Obviously, an examining physician must decide what is best to try for each patient's individual condition. We also use zinc acetate or at times trientene in preference to penicillamine due to the risk of making neurologic disease worse on penicillamine. Consider getting Dr. Brewer's book on the treatment of Wilson's disease. ...
What is the mechanism of action of Zanaflex Capsules?
Zanaflex Capsules work in the brain and in the spinal cord. Based on animal models, Zanaflex Capsules reduce activity in the locus ceruleus. In the spinal cord, Zanaflex Capsules reduce the release of excitatory neurotransmitters and also reduce the sensitivity of the synaptic cleft to excitatory neurotransmitters by working within polysynaptic pathways. Click Here for more information. Important Safety Information The use of fluvoxamine or ciprofloxacin is contraindicated with tizanidine. ...
Is there a sample program for Zanaflex Capsules?
Yes. The sampling program offers a starter supply of Zanaflex Capsules for your patients. For more information please contact Acorda Medical Information at 1-800-367-5109 or Click Here .
Is there a food effect with Zanaflex Capsules?
Yes. Food has complex effects on tizanidine pharmacokinetics, which differ with the different formulations. Peak Plasma levels of tizanidine when administered with food: Increase 30% when taking tablets Decrease 20% when taking Zanaflex Capsules These changes may result in increased adverse events or delayed/more rapid onset of activity, depending upon the nature of the switch. Click Here to find out more. Important Safety Information The use of fluvoxamine or ciprofloxacin is contraindicated with tizanidine. ...
How do Zanaflex Capsules work?
Zanaflex Capsules work in the brain and spinal cord to change the messages being sent to the muscles and thereby reduce spasticity. In clinical studies, people taking the drug had fewer muscle spasms than people taking a placebo (sugar pill). Zanaflex Capsules can reduce the increased muscle tone that is causing your spasticity, without affecting your muscle strength. Zanaflex Capsules are non-narcotic. ...
What should I do if I miss a dose of Zanaflex?
If you miss a dose of Zanaflex, take it as soon as you remember it. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do NOT double the dose to make up for a missed dose. Do not take more tablets than your doctor prescribed.
Who should take Zanaflex?
You should not take Zanaflex if you are allergic to Zanaflex, Tizanidine or any component of the drug. It's important to let your physician know, during either a physical or online consultation, about any prescription or over-the-counter medications you're taking, especially any sedatives, antihypertension medications or birth control medications (See What are the possible drug interactions of Zanaflex? ...
How can I get an Zanaflex prescription online?
Go to our Zanaflex price comparison page where you can select your preferred online US pharmacy with the lowest Zanaflex prices, no prior prescription needed . Our featured US-based online pharmacies work with US-licensed doctors and pharmacists to provide you with your prescriptions through an online consultation. If this is your first time ordering Zanaflex online, see our beginner’s guide , where the process of obtaining a prescription online and ordering your medication is explained.
What are the most important drug interactions with Zanaflex Capsules?
Use of fluvoxamine or ciprofloxacin with tizanidine is contraindicated. Concurrent use results in significant increases in tizanidine plasma levels. Zanaflex has been shown to interact with acetaminophen, alcohol and oral contraceptives. Alcohol and oral contraceptives each affect the pharmacokinetics of tizanidinde. Please review the full prescribing information. Important Safety Information The use of fluvoxamine or ciprofloxacin is contraindicated with tizanidine. Tizanidine occasionally causes liver injury. ...
How can I get started on Zanaflex Capsules?
Your doctor will determine if Zanaflex Capsules are the right choice for you. Only your doctor can prescribe Zanaflex Capsules
Do Zanaflex Capsules come in different strengths?
Zanaflex Capsules are available in 2 mg, 4 mg and 6 mg strengths. Since the capsule is available in three strengths, your doctor will recommend what doses you should take and how often to take them. Be sure to follow your doctor’s instructions carefully
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