Kidney transplantation: Frequently Asked Questions
WHAT IS KIDNEY TRANSPLANTATION?
A kidney transplant is a surgical procedure in which a kidney is removed from one person (donor) and placed into the body of a person suffering from renal failure (recipient), in whom the transplanted kidney can perform all the functions which the patient's own kidneys are not able to perform.
Source: www.dilipraja.com
In place of dialysis, for a patient with no kidney function, sometimes kidney transplantation is an option. A kidney transplant comes from an anonymous kidney donor or a living person. (See illustration) Obtaining a kidney transplant is a lengthy process which can exceed two years. Because of this lengthy wait, many patients do dialysis therapy while waiting for a kidney transplant.
Source: ninephrology.com
Who needs a kidney transplantation?
Any patient who suffers from severe irreversible loss of kidney function. This condition is also called 'terminal renal failure' (TRF). Whithout sufficient kidney function life can only be sustained by chronic dialysis treatment.
Source: www.medizin.fu-berlin.de
What is the concept of kidney "matching" in kidney transplantation: ?
In addition to the blood group HLA matching is done. HLA (human leukocyte antigens) are proteins present on white blood cells that are the products of closely linked genes on chromosomes no 6. There are more than 100 such identifiably proteins. They are divided into different classes A, B C and D and DR . For each of these subgroups the matching is done.
Source: www.aarogya.com
Who is a candidate for kidney transplantation?
Individuals with end-stage kidney disease may be eligible for a kidney transplant.
Source: www.emoryhealthcare.org
Why is there a waiting list for kidney transplantation?
Because too few organs for transplantation are available. The waiting time of the patients can only become shorter by improving organ donation . The number of transplant centers and the surgical resources are sufficiently available. In addition the patients have to wait until a kidney with a good matched tissue type has been found.
Source: www.medizin.fu-berlin.de
What is kidney transplantation surgery like for the recipient?
Regardless of whether the kidney is from a living or deceased donor, the transplant operation for the recipient involves general anesthesia and treatment with anti-rejection drugs before the transplant. A small cut (approximately 4 to 5 inches long) is typically made in the lower left side of the abdomen, and the kidney is placed into the space The blood vessels of the donor kidney are sewn to the recipient's blood vessels Then the surgeon connects the ureter to the bladder and closes the cut The recipient operation usually ...
Source: www.transplantexperience.com
What is the percentage of rejection in kidney transplantation?
With current treatment for kidney transplants, early rejection is now down to about 15 percent. Most of these people will not lose the kidney from rejection. In the longer term, what is called chronic rejection, can cause the loss of about half of kidneys during a patients lifetime.
Source: lib.cpums.edu.cn
Is life after kidney transplantation completely normal?
After kidney transplantation a continous drug treatment ( immunosuppression ) is neccessary to avoid an advers reaction of the recipients immun system (graft rejection) directed against the transplanted kidney. These drugs do not only suppress graft rejection but also produce an increased risk for infectious diseases and - to a small extent - for tumors. In addition these agents can produce side effects depending on which substance is used. ...
Source: www.medizin.fu-berlin.de
Who May Consider Living Donor Kidney Transplantation?
All patients waiting for a kidney transplant should consider living donor transplantation. The philosophy of the transplant team is that anyone listed for a kidney transplant is encouraged to discuss this option with family members and close friends.
Source: surgery.med.nyu.edu
Who can I turn to for any questions I have about kidney transplantation?
You can turn to the transplant team at the Heidelberg Transplant Center, where you will be given an appointment. >>contact
Source: www.klinikum.uni-heidelberg.de
What were the results of the voclosporin Phase 2a kidney transplantation trial?
The primary endpoint of the trial was to demonstrate that stable kidney transplant patients receiving mix-voclosporin experienced no negative change in kidney function when compared to patients on cyclosporine (Neoral®). The secondary endpoint of the study was to measure the pharmacodynamics and pharmacokinetics of mix-voclosporin in renal transplant patients. All of these endpoints were achieved. ...
Source: www.isotechnika.com
Do you offer living donor kidney transplantation?
Yes. Kidneys can come from both deceased and living donors. Deceased (cadaveric) donors are donors who have been declared brain dead and whose families have agreed to organ donation. This has been the main source of transplantable kidneys. However, kidney donations from living donors are increasing. Click to view additional information about our live donor kidney transplant program.
Source: www.ukhealthcare.uky.edu
What diseases or conditions commonly lead to kidney transplantation?
Adults The most common causes of kidney failure in adults are long-term complications of diabetes (high blood sugar) and hypertension (high blood pressure). Other diagnoses that lead to kidney disease in adults include systemic lupus erythematosus, polycystic kidney disease, and glomerulonephritis . Children Causes of kidney disease in children and adults are generally very different. Children often have a higher rate of inherited (congenital) or metabolic disease present at birth and abnormally developed urinary systems. ...
Source: www.transplantexperience.com
What were the results of the voclosporin Phase IIa kidney transplantation trial?
The primary endpoint of the trial was to demonstrate that stable kidney transplant patients receiving mix-voclosporin experienced no negative change in kidney function when compared to patients on cyclosporine (Neoral®). The secondary endpoint of the study was to measure the pharmacodynamics and pharmacokinetics of mix-voclosporin in renal transplant patients. All of these endpoints were achieved. ...
Source: www.isotechnika.com
Who is a candidate for a kidney transplant and what are the types of transplantation possible?
People whose kidneys have permanently failed due to chronic end-stage renal disease caused by diabetes mellitus, hypertension, autoimmune disease, congenital abnormalities or because of infection or trauma (injury) may be candidates for a kidney transplant. There are two ways a kidney can be donated: Deceased donor: A donated kidney from a person who has irreversible brain injury and has previously registered to become an organ donor or the family wishes to donate. ...
Source: medicalcenter.osu.edu
Which HLA typing tests should I order for kidney transplantation?
Tests for screening solid organ transplant recipient and potential donor(s) prior to enrollment in a transplant registry include: HLA Class I A, B, C DNA Typing (15484X) HLA Class II DR, DQ DNA Typing (15485X)
Source: www.questdiagnostics.com
Do the patients require dialysis after the kidney transplantation?
Most of the cases the grafted kidney starts functioning immediately. Such patents does not require the dialysis. In rare cases, some patients may require few dialysis after transplantation, till the transplanted kidney functions.
Source: steroidsfree.com
Then why not use the drugs that make possible kidney and liver transplantation?
There are four reasons. First, the drugs have side effects which are worse than the problems associated with insulin therapy, and such immunosuppressive drugs must be used for the remainder of the recipient's life. Second, islets are more susceptible to rejection than other organs. Third, human islets are so scarce that animal islets are needed, and immune suppression does not work with animal tissues. Fourth, islets are sensitive to the toxic effects of commonly used immunosuppressive drugs.
Source: www.isletmedical.com
